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Biomedical Physics Program

Magnetic Resonance

The 2003 Nobel Prize in Physiology/Medicine was awarded to two scientists: Paul C. Lauterbur and Peter Mansfield who made seminal discoveries that were the basis for the development of magnetic resonance into a useful imaging method.

Stepping through the brain (click for movie)

MRI: Stepping through the anatomy

In the last two decades, the technology of MRI has developed rapidly making tremendous contribution in medicine. In 2002, approximately 22,000 MRI scanners were in use worldwide, and more than 60 million examinations were performed. All the sophisticated detail of an MRI scan, particularly in the case of brain and spinal cord exam, comes without the use of ionizing radiation. Improved diagnosis in cancer, the use of detailed three-dimensional images as a pre-operative tool, along with non-invasive angiography has all contributed to reducing suffering for the patient.

New Technologies in MR:

MRS: Physicians have long realized that to understand the play of the dynamics within the human organism, one must not only be able to read the script, i.e., visualize the anatomy but also participate in authoring the script at a biochemical and molecular level. Hence, more and more, technologies are trying to look at biochemistry and functioning of the organism at a molecular level. One such technology is magnetic resonance spectroscopy. MRS may reveal a metabolite that is not normally present or an abnormal quantity of a metabolite that is usually present.

Differences in Brain SpectraDifferences in Brain Spectra between Tumor and Normal Tissue
Magnetic resonance spectrummagnetic resonance spectrum (MRS)

2D MRS (contour plot) showing more cerebral metabolites and
better separation

Functional MRI: fMRI refers to a phenomenon discovered in the early 1990s – Blood Oxygenation Level Dependent (BOLD) effect. MR signal can be made sensitive to local changes in the oxygenation of the blood following neural activation. Local neural activation increases local cerebral blood flow more than local oxygen metabolism rate so blood oxygenation increases in activated parts of the brain.

Differences in Brain SpectrafMRI cortical activation
[Image courtesy]

Diffusion and Perfusion MRI: These techniques stand at the forefront of physiologically-sensitive radiologic imaging. Diffusion imaging is designed to study the movement of water molecules. Such a study finds a range of applications in stroke, infection, and metabolic diseases. In addition, the advent of white matter fiber tracking via the techniques heralds a new application. Perfusion-weighted imaging assesses the perfusion of the microvasculature after rapid injection of a gadolinium contrast agent.